Pathophysiology of Osteonecrosis of the Jaws

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Bisphosphonate-related osteonecrosis of the jaws (Bronj)

UNLABELLED Bisphosphonate-related osteonecrosis of the jaws (BRONJ) is an extremely therapy resistant osteomyelitis-like disease exclusively involving the jaw bones of patients in treatment with bisphosphonates (BPs). OBJECTIVES The aim of this study was to evaluate the radiological and clinical findings and management of 51 patients with BRONJ diagnosed from 2004 to 2009 in our Reference Cen...

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Biophosphonate-related osteonecrosis of the jaws.

In 2003 and 2004, the first reports of patients who developed necrosis of the jawbones while taking biophosphonates appeared in literature; most patients were on this drug for treatment of cancer and some osteoporosis. Since then, more than 500 cases have been identified and the number of these cases continues to grow. This article reviews the action of bisphosphonates, the condition called bis...

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[Bisphosphonates and osteonecrosis of the jaws].

The osteonecrosis of the jaws (ONJ) has been reported occasionally in cancer patients treated with radiotherapy and chemotherapy. However, bisphosphonate (BP)-associated ONJ in patients with cancer such as multiple myeloma, breast cancer and prostate cancer mainly administered with intravenous BPs has been first reported in 2003. Since then, many cases over 2,500 are accumulating worldwide. Sin...

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ژورنال

عنوان ژورنال: Oral and Maxillofacial Surgery Clinics of North America

سال: 2015

ISSN: 1042-3699

DOI: 10.1016/j.coms.2015.06.001